Name | Suxamethonium Chloride |
Classes |
Central Nervous System Agent Anesthetic |
Diseases |
Neuromascular Disorder Paralysis |
Bangla
Suxamethonium Chloride
Suxamethonium Chloride belongs to the class of drugs known as depolarizing neuromuscular blockers. It acts as a skeletal muscle relaxant by mimicking the action of acetylcholine at the neuromuscular junction. It binds to nicotinic acetylcholine receptors, causing depolarization and subsequent muscle paralysis.
- Suxamethonium chloride Injection is an ultra-short acting, depolarising, neuromuscular blocking agent. It is used in anaesthesia as a skeletal muscle relaxant to facilitate tracheal intubation and mechanical ventilation surgical procedures.
- Suxamethonium chloride injection is also used to reduce the intensity of muscular contractions associated with pharmacologically or electrically-induced convulsions.
- The dosage of Suxamethonium Chloride should be individualized based on the patient's age, weight, and clinical condition.
- The medication is administered intravenously and should be given by a trained healthcare professional.
- The recommended initial dose for adults is typically 1 to 1.5 mg/kg, with a maximum dose of 150 mg. Repeat doses may be required to maintain muscle relaxation during prolonged procedures.
Adverse reactions to Suxamethonium Chloride may occur and can include:
- Fasciculations (brief, involuntary muscle twitches)
- Muscle pain or soreness
- Hyperkalemia (high potassium levels in the blood)
- Transient increase in intraocular pressure (rare)
- Transient increase in intragastric pressure (rare)
- Bradycardia (slow heart rate)
- Malignant hyperthermia (rare but potentially life-threatening reaction)
- Suxamethonium Chloride should only be administered by healthcare professionals trained in the use of neuromuscular blockers and airway management.
- The medication should be used with caution in patients with a history of malignant hyperthermia, muscle disorders, or electrolyte imbalances.
- Suxamethonium Chloride can cause a rapid and profound decrease in respiratory function, necessitating mechanical ventilation. Adequate ventilation and oxygenation must be ensured during its use.
- Hyperkalemia, a potentially serious adverse reaction, may occur, particularly in patients with burns, trauma, denervation, or certain neuromuscular disorders.
- Malignant hyperthermia, characterized by hypermetabolism and elevated body temperature, is a rare but potentially fatal reaction to Suxamethonium Chloride. Immediate treatment, including discontinuation of the drug, should be initiated if malignant hyperthermia is suspected.
Contraindication
- Suxamethonium Chloride is contraindicated in patients with a known hypersensitivity to the medication.
- It should not be used in patients with a history of malignant hyperthermia or a family history of the condition.
- The medication should be avoided in patients with severe skeletal muscle myopathies or neuromuscular disorders such as myasthenia gravis or Eaton-Lambert syndrome.
- It should not be used in patients with a history of malignant hyperthermia or a family history of the condition.
- The medication should be avoided in patients with severe skeletal muscle myopathies or neuromuscular disorders such as myasthenia gravis or Eaton-Lambert syndrome.