Medicine details
Image | |
Name | Montelon 10 |
Dosage | Tablet |
Generic Name | Montelukast |
Classes |
Respiratory Agent Antiasthmatic Antiallergic Agent |
Diseases |
Asthma Respiratory Disease Runny Nose Sneezing |
Company | Apex Pharmaceuticals Ltd. |
Drug Package Details
Strength | 10 mg |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 20 |
Price per pack | ৳ 200.00 |
Cost per pack | ৳ 176.00 |
Package unit | 10 tabs strip |
Price per unit | ৳ 10.00 |
Cost per unit | ৳ 8.80 |
Discount | 0 |
Coupon | |
Remarks |
Montelukast
Montelukast belongs to a class of drugs called the leukotriene receptor antagonist. The cysteinyl leukotrienes (LTC4 , LTD4 , LTE4 ) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. The CysLT type-1 (CysLT1) receptor is found in the human airway (including airway smooth muscle cells and airway macrophages) and on other pro-inflammatory cells (including eosinophils and certain myeloid stem cells). Montelukast causes inhibition of airway cysteinyl leukotriene receptors.
Montelukast is a leukotriene receptor antagonist indicated for:
- Prophylaxis and chronic treatment of asthma in patients 12 months of age and older
- Acute prevention of exercise-induced bronchoconstriction (EIB) in patients 6 years of age and older
- Relief of symptoms of allergic rhinitis (AR): seasonal allergic rhinitis (SAR) in patients 2 years of age and older, and perennial allergic rhinitis (PAR) in patients 6 months of age and older
- Asthma: Once daily in the evening for patients 12 months and older.
- Acute prevention of EIB: One tablet at least 2 hours before exercise for patients 6 years of age and older.
- Seasonal allergic rhinitis: Once daily for patients 2 years and older.
- Perennial allergic rhinitis: Once daily for patients 6 months and older.
Dosage (by age)
- 15 years and older: one 10-mg tablet.
- 6 to 14 years: one 5-mg chewable tablet.
- 2 to 5 years: one 4-mg chewable tablet or one packet of 4-mg oral granules.
- 6 to 23 months: one packet of 4-mg oral granules.
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening.
For oral granules: Must administer within 15 minutes after opening the packet (with or without mixing with food)
Oral granules |
Most common adverse reactions associated with montelukast are:
- upper respiratory infection
- fever
- headache
- pharyngitis
- cough
- abdominal pain
- diarrhea
- influenza
- rhinorrhea
- sinusitis
- otitis
- Do not prescribe Montelukast to treat an acute asthma attack
- Advise patients to have appropriate rescue medication available
- Inhaled corticosteroid may be reduced gradually. Do not abruptly substitute Montelukast for inhaled or oral corticosteroids
- Patients with known aspirin sensitivity should continue to avoid aspirin or non-steroidal anti-inflammatory agents while taking Montelukast
- Neuropsychiatric events have been reported with Montelukast. Instruct patients to be alert for neuropsychiatric events. Evaluate the risks and benefits of continuing treatment with Montelukast if such events occur
- Systemic eosinophilia, sometimes presenting with clinical features of vasculitis consistent with Churg-Strauss syndrome, has been reported. These events usually, but not always, have been associated with the reduction of oral corticosteroid therapy
- Inform patients with phenylketonuria that the 4-mg and 5-mg chewable tablets contain phenylalanine
Contraindication
Contraindicated in patients hypersensitive to Montelukast.
None known.
None known.