Retapamulin ointment is indicated for the topical treatment of impetigo caused by susceptible strains of Staphylococcus aureus (methicillin-susceptible strains) and Streptococcus pyogenes in patients aged 9 months and older.

Impetigo

• For topical use only.
• Apply a thin layer of retapamulin ointment to the affected area twice daily for 5 days.
• The ointment should be gently rubbed into the skin until it disappears.
• The treated area should not be covered with occlusive dressings.

The most common adverse reactions (≥1%) reported in clinical trials include:

• Application site irritation
• Application site pruritus (itching)
• Application site pain or discomfort

Irritation

Pruritus

Pain

• Hypersensitivity: Discontinue use if a hypersensitivity reaction occurs and initiate appropriate therapy.
• Non-susceptible organisms: Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If secondary infection occurs during treatment, appropriate alternative therapy should be considered.
• Eye contact: Avoid contact with the eyes. If accidental eye exposure occurs, rinse thoroughly with water.
• Pregnancy and breastfeeding: There are no adequate and well-controlled studies in pregnant or breastfeeding women. Use retapamulin during pregnancy or breastfeeding only if clearly needed.