Artemether is rarely used alone, it is almost always used in combination with lumefantrine to treat malaria.

Malaria

• Artemether is administered in combination with lumefantrine. The dosage is as follows-
  • 5 to < 15 kg: 1 tablet
  • 15 to < 25 kg: 2 tablets
  • 25 to < 35 kg: 3 tablets
  • 35 kg and over: 4 tablets
• Each tablet contains 120 mg lumefantrine and 20 mg artemether.
• This medication should be taken with food & maybe crushed while taking.
• Tablets should be administered over 3 days for a total of 6 doses: an initial dose, second dose after 8 hours and then twice-daily (morning and evening) for the following 2 days.

Artemether (along with lumefantrine) may cause the following side effects-

• headache
• anorexia
• dizziness
• asthenia
• arthralgia
• myalgia

Headache	Anorexia	Dizziness
Asthenia	Arthralgia	Myalgia

The most common adverse reactions in children (greater than 12%) are pyrexia, cough, vomiting, anorexia, and headache.

• Patients with known QT prolongation, hypokalemia or hypomagnesemia, and those taking other drugs that prolong the QT interval should avoid using it.
• Due to limited safety data, antimalarials should not be given concurrently unless there are no other treatment options.
• Following Artemether (along with lumefantrine) Tablets, QT prolonging drugs such as quinine and quinidine should be used with caution.
• Substrates, inhibitors, or inducers of CYP3A4, including antiretroviral medications, should be used with caution with Artemether (along with lumefantrine) Tablets due to the possibility of decreased efficacy or additive QT prolongation.