Name Flumequine
Classes Antiinfective Agent
Antibiotic
Quinolone
Diseases Veterinary Infection

Flumequine

Flumequine is classified as a quinolone antibiotic. It inhibits bacterial DNA synthesis by interfering with DNA gyrase, an enzyme necessary for the replication and repair of bacterial DNA.

Flumequine is indicated for the treatment of susceptible veterinary bacterial infections, including but not limited to:

  • Urinary tract infections.
  • Respiratory tract infections.
  • Gastrointestinal infections.
  • Skin and soft tissue infections.
  • Dosage may vary based on the specific infection and patient factors. Dosage should be individualized.
  • The duration of treatment should be determined by the nature and severity of the infection.

Most Common:

  • Gastrointestinal disturbances (nausea, vomiting, diarrhea).
  • Central nervous system effects (dizziness, headache).
  • Skin reactions (rash).
  • Tendinitis and Tendon Rupture: Quinolones, including flumequine, may cause tendinitis and tendon rupture, particularly in older adults.
  • Central Nervous System Effects: Use caution in patients with known or suspected central nervous system disorders.
  • Photosensitivity: Avoid excessive sunlight or artificial UV light during treatment.
  • Clostridium difficile-Associated Diarrhea (CDAD): Consider CDAD in patients presenting with diarrhea after antibacterial use.

Contraindication

Hypersensitivity: Contraindicated in individuals with a history of hypersensitivity to quinolones.

  • Pregnancy and Lactation: Use during pregnancy and lactation should be avoided unless the potential benefits justify the potential risks.
  • Pediatric Use: Safety and effectiveness in pediatric patients have not been established.