• Estriol is indicated for the treatment of moderate to severe symptoms of vulvar and vaginal atrophy due to menopause.
• It is used to relieve symptoms such as vaginal dryness, itching, burning, and discomfort during sexual intercourse.

Vaginal Dryness

Sexual Dysfunction

• The dosage of Estriol may vary depending on the individual and the severity of symptoms.
• It is available in different forms, including creams, vaginal suppositories, and tablets.
• The healthcare provider will determine the appropriate dosage and administration method for each patient.
• It is important to follow the prescribed dosage and administration instructions provided by the healthcare provider.

Side effects of estriol include-

• Local irritation or discomfort at the application site (in the case of topical formulations).
• Vaginal discharge or spotting.
• Breast tenderness or enlargement.
• Headache.
• Nausea.
• Abdominal pain or bloating.
• Fluid retention.
• Mood changes or emotional instability.
• Skin reactions (rash, itching).

Irritation

Vaginal Discharge

Breast Tenderness

Fluid Retention

• Endometrial cancer: Estriol should be used with caution in women with a history of endometrial cancer or other estrogen-dependent tumors.
• Breast cancer: Estriol should not be used in women with a history of breast cancer or other estrogen-dependent tumors.
• Cardiovascular disorders: Estriol may increase the risk of cardiovascular events such as heart attack, stroke, and blood clots. It should be used with caution in women with a history of cardiovascular disease or risk factors.
• Gallbladder disease: Estriol may increase the risk of gallbladder disease. Caution is advised in patients with a history of gallbladder problems.
• Liver impairment: Estriol should be used with caution in patients with liver impairment or disease.
• Hormone-sensitive cancers: Estriol may stimulate the growth of hormone-sensitive tumors. It should not be used in patients with known or suspected hormone-sensitive cancers.
• Pregnancy and breastfeeding: Estriol is not intended for use during pregnancy or while breastfeeding.