Cyproheptadine is indicated for the following conditions-

• Perennial and seasonal allergic rhinitis
• Vasomotor rhinitis
• Allergic conjunctivitis due to inhalant allergens and foods
• Mild, uncomplicated allergic skin manifestations of urticaria and angioedema.
• Amelioration of allergic reactions to blood or plasma
• Cold urticaria
• Dermatographism
• As therapy for anaphylactic reactions adjunctive to epinephrine and other standard measures after the acute manifestations have been controlled.

Allergic rhinitis

Conjunctivitis

Cold urticaria

Allergic Reaction

• DOSAGE SHOULD BE INDIVIDUALIZED ACCORDING TO THE NEEDS AND THE RESPONSE OF THE PATIENT.
• Each tablet contains 4 mg of cyproheptadine hydrochloride.
• Patients between the ages of 2 and 6 years:
  • The total daily dosage for pediatric patients can be estimated using 0.25 mg/kg/day or 8 mg per 2 square meter of body surface (8 mg/m) based on body weight or body area.
  • The normal dose is 2 mg (1/2 tablet) two or three times a day, adjusted as needed depending on the patient's size and response. The daily intake should not exceed 12 mg.

• 7 to 14 years old:
  • The normal dose is 4 mg (1 tablet) two or three times a day, adjusted as needed depending on the patient's size and response. The daily intake should not exceed 16 mg.

• Adults:
  • For adults, the total daily dose should not exceed 0.5 mg/kg/day. The daily dose ranges from 4 to 20 mg, with the majority of patients requiring 12 to 16 mg. For sufficient treatment, an uncommon patient may need as much as 32 mg per day. Starting with 4 mg (1 tablet) three times a day, the dosage should be modified according to the patient's physique and response.

CNS: dizziness, disturbed coordination, confusion, restlessness, excitation, nervousness, tremor, irritability, insomnia, paresthesias, neuritis, convulsions, euphoria, hallucinations, hysteria, faintness.

Cardiovascular: Hypotension, palpitation, tachycardia, extrasystoles, anaphylactic shock.

Hematologic: Hemolytic anemia, leukopenia, agranulocytosis, thrombocytopenia.

Digestive System: Cholestasis, hepatic failure, hepatitis, hepatic function abnormality, dryness of mouth, epigastric distress, anorexia, nausea, vomiting, diarrhea, constipation, jaundice.
Genitourinary: Urinary frequency, difficult urination, urinary retention, early menses.
Respiratory: Dryness of nose and throat, thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness.

Dizziness	Insomnia (Difficulty in Falling asleep)	Hypotension	Tachycardia
Anemia	Jaundice	Dry Mouth	Nausea

• Cyproheptadine has an atropine-like action and, therefore, should be used with caution in patients with:
  
  • History of bronchial asthma
  • Increased intraocular pressure
  • Hyperthyroidism
  • Cardiovascular disease
  • Hypertension
• Antihistamines might reduce mental alertness; nevertheless, they can also cause excitement, especially in young children.
  Patients should be advised against participating in activities that require mental awareness and motor coordination, such as driving a car or operating machinery.