Name | Ipratropium Bromide + Salbutamol |
Classes |
Respiratory Agent Antiasthmatic Adrenergic Bronchodilator |
Diseases |
Chronic Obstructive Pulmonary Disease (COPD) Respiratory Disease |
Ipratropium Bromide + Salbutamol
Ipratropium bromide is an anticholinergic (parasympatholytic) agent which, based on animal studies, appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter agent released at the neuromuscular junctions in the lung. Anticholinergics prevent the increases in intracellular concentration of Ca++ which is caused by interaction of acetylcholine with the muscarinic receptors on bronchial smooth muscle. Salbutamol is a beta2 adrenergic receptor agonist that binds to the receptors present in the airways and causes broncho dilation.
The usual adult dose is 1 to 2 puffs of the MDI or 2.5 mL of the nebulizer solution four times a day.
Common side effects of Ipratropium Bromide and Salbutamol include dry mouth, throat irritation, headache, upper respiratory infection, nasopharyngitis, cough, bronchitis, headache, and dyspnea.
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Drowsiness and dizziness: Ipratropium Bromide and Salbutamol may cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.
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Cardiovascular effects: Ipratropium Bromide and Salbutamol may cause an increase in heart rate and blood pressure. If you have a history of heart disease, consult your doctor before using this medication.
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Glaucoma: Ipratropium Bromide and Salbutamol may cause an increase in intraocular pressure and should be used with caution in patients with glaucoma.
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Thyroid disease: Ipratropium Bromide and Salbutamol may exacerbate symptoms of hyperthyroidism. Consult your doctor before using this medication if you have thyroid disease.
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Pregnancy and breastfeeding: Ipratropium Bromide and Salbutamol should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if Ipratropium Bromide and Salbutamol passes into breast milk. Consult your doctor before breastfeeding.
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Drug interactions: Ipratropium Bromide and Salbutamol may interact with other medications you are taking. Be sure to tell your doctor about all the medications you are taking, including prescription and non-prescription drugs, vitamins, and herbal supplements.
Contraindication
Contraindicated in patients with-
- Hypersensitivity to any of the ingredients in Ipratropium Bromide + Salbutamol
- Hypersensitivity to atropine or any of its derivatives
None known.
None known.