Candesartan Cilexetil + Hydrochlorothiazide is indicated for the treatment of-

• Hypertension

Hypertension (Hight Blood Pressure)

• When used as monotherapy in individuals who are not volume deficient, the normal suggested beginning dose of candesartan cilexetil is 16 mg once daily. Tablets of candesartan cilexetil can be used once or twice a day, with total daily doses ranging from 8 mg to 32 mg. Patients who require further blood pressure lowering should be titrated to 32 mg. Larger doses do not appear to have a bigger lowering effect on blood pressure.
• Hydrochlorothiazide is effective in doses of 12.5 to 50 mg once daily.
• Use in moderate to severe Hepatic Impairment: Candesartan cilexetil and hydrochlorothiazide are not advised for initiation in moderate to severe hepatic impairment because the necessary starting dose, 8 mg, cannot be given.

The side effects associated with the medication are as follows-

• headache
• dizziness
• Pharyngitis
• Hypotension
• Tinnitus
• Dyspepsia
• Asthenia

Headache	Dizziness	Asthenia
Hypotension	Dry Cough	Dyspepsia

• During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
• Symptomatic hypotension can occur in patients with an active renin-angiotensin system, such as volume- and/or salt-depleted patients on high doses of diuretics.
• Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on Candesartan Cilexetil + Hydrochlorothiazide.