This combination is indicated for the treatment of bacterial infections caused by susceptible organisms, including:

• Upper and lower respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections
• Gastrointestinal tract infections
• Bone and joint infections
• Endocarditis
• Septicemia
• Dental infections

URTI (Upper Respiratory Tract Infection)	Skin Infection	UTI (Urinary Tract Infection)
Abdominal Infection	Bone Infection	Septicemia

The dosages of amoxicillin and cloxacillin are combined and given orally, typically three to four times a day, depending on the severity of the infection and the patient's age and weight. The usual adult dosage is 500 mg of each drug, while the pediatric dosage is based on the child's weight. The duration of treatment may range from 5 to 14 days, depending on the type and severity of the infection.

The most common adverse reactions associated with amoxicillin and cloxacillin use include:

• Diarrhea
• Nausea and vomiting
• Rash
• Hypersensitivity reactions
• Superinfection with non-susceptible organisms
• Hepatitis

Diarrhea

Nausea

Rash

Hepatitis

• Hypersensitivity reactions: Patients with a history of hypersensitivity to penicillins should not receive amoxicillin and cloxacillin. Allergic reactions, including anaphylaxis, may occur and can be life-threatening. Patients should be carefully monitored for signs of hypersensitivity during therapy.
• Superinfection: Prolonged use of amoxicillin and cloxacillin may result in the overgrowth of nonsusceptible bacteria or fungi. Patients should be monitored for signs of superinfection and treatment should be adjusted accordingly.
• Renal impairment: Amoxicillin and cloxacillin are primarily excreted by the kidneys. Dosage adjustments are recommended in patients with renal impairment to avoid drug accumulation and toxicity.
• Hepatic impairment: Patients with hepatic impairment may require dose adjustments due to reduced drug metabolism and clearance.
• Pregnancy and lactation: The safety of amoxicillin and cloxacillin use during pregnancy and lactation has not been established. Use during these periods should be done only if the benefits outweigh the risks.