Tazobactam is indicated for use in combination with certain beta-lactam antibiotics to treat infections caused by susceptible bacteria. It is often used in combination with piperacillin, a broad-spectrum penicillin, to broaden the spectrum of antibacterial activity.

Bacterial Infection

The recommended dose typically involves the co-administration of tazobactam with a beta-lactam antibiotic. Dosage and duration depend on the severity of the infection and the specific antibiotic used.

Adverse reactions associated with tazobactam are-

• Diarrhea
• Nausea
• Rash
• Headache
• Vomiting
• Increased liver enzymes
• Injection site reactions
• Hypersensitivity reactions (e.g., anaphylaxis)

Diarrhea

Nausea

Rash

Headache

• Hypersensitivity Reactions: Monitor patients for signs of hypersensitivity reactions, including rash, fever, and anaphylaxis. Discontinue treatment if an allergic reaction occurs and initiate appropriate medical therapy.
• Clostridium difficile-associated Diarrhea (CDAD): Consider CDAD in patients presenting with diarrhea after antibiotic use. Discontinue Tazobactam if CDAD is suspected or confirmed and initiate appropriate treatment.
• Renal Impairment: Adjust dosage in patients with renal impairment to prevent accumulation of the drug and potential toxicity. Monitor renal function regularly.
• Seizures: Use with caution in patients with a history of seizures or central nervous system disorders. Seizures have been reported in patients treated with beta-lactam antibiotics, including tazobactam.
• Superinfection: Prolonged use may result in overgrowth of nonsusceptible organisms, including fungi. Monitor patients for superinfections and institute appropriate therapy if necessary.