• Tapentadol is indicated for the management of moderate to severe acute pain in adults.
• It is used when alternative treatments are inadequate or not tolerated.

Pain

• The dosage of Tapentadol should be individualized based on the patient's pain severity, response, and tolerability.
• The recommended starting dose is 50 to 100 mg orally every 4 to 6 hours as needed for pain.
• The maximum daily dose is 600 mg.
• The dose may be adjusted based on the patient's needs and response, but caution should be exercised to avoid overdose or adverse effects.

The following side effects have been reported with the use of Tapentadol

• Nausea
• Vomiting
• Dizziness
• Constipation
• Headache
• Somnolence
• Pruritus
• Sweating
• Fatigue
• Dry mouth

Nausea	Vomiting	Dizziness
Somnolence	Headache	Constipation

• Tapentadol has a risk of respiratory depression, misuse, abuse, addiction, and overdose. It should be prescribed and administered with caution, especially in patients with a history of substance abuse or addiction.
• Prolonged use of Tapentadol may lead to physical dependence and withdrawal symptoms upon abrupt discontinuation.
• Tapentadol should be used with caution in patients with impaired respiratory function, liver or kidney disease, or a history of seizures.
• Concurrent use of Tapentadol with other central nervous system depressants, including alcohol, may potentiate respiratory depression and sedation.
• Tapentadol may impair mental or physical abilities required for driving or operating machinery, and patients should be advised to avoid such activities until they know how the medication affects them.
• Seizures:  Use with caution in patients with a history of seizures.
• Serotonin Syndrome: Potentially life-threatening condition could result from concomitant serotonergic administration.