• Silodosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH).
• It helps to improve urinary flow and relieve symptoms such as hesitancy, weak stream, and incomplete emptying of the bladder.

Benign prostatic hyperplasia (BPH)

Urinary retention

• The dosage of Silodosin should be individualized based on the patient's age, medical condition, and response to therapy.
• The recommended dose for adults is usually 8 mg orally once daily with a meal.
• 4 mg capsules taken orally once daily with a meal for those with moderate renal impairment [Creatinine Clearance (CCr) 30-50 mL/min]
• Silodosin should be taken at the same time each day to maintain a consistent level of the drug in the body.

Adverse reactions to Silodosin may include:

• Retrograde ejaculation (semen going into the bladder instead of out of the penis)
• Dizziness or lightheadedness
• Headache
• Runny or stuffy nose
• Diarrhea
• Abnormal ejaculation (decreased semen volume)
• Decreased blood pressure leading to orthostatic hypotension (feeling dizzy or lightheaded when standing up)

Dizziness

Headache

Diarrhea

Hypotension (Low Blood Pressure)

• Silodosin may cause a condition known as retrograde ejaculation, where semen goes into the bladder instead of being ejaculated. While this is not harmful, patients should be informed about this potential side effect.
• The drug may cause dizziness or lightheadedness, especially when getting up from a sitting or lying position. Patients should be advised to rise slowly to minimize this effect.
• Silodosin may interact with other medications, especially those that lower blood pressure, leading to increased hypotensive effects. Therefore, it is essential to inform the healthcare provider about all other medications being taken.
• Caution should be exercised in patients with severe liver or kidney impairment, as dosage adjustments may be necessary.