Roxatidine is indicated for the treatment of:

• Active duodenal ulcer
• Active benign gastric ulcer
• Gastroesophageal reflux disease (GERD)
• Zollinger-Ellison syndrome

Duodenal Ulcer

Gastric Ulcer

GERD (Gastroesophageal Reflux Disease)

Zollinger-Ellison Syndrome

• The dosage of roxatidine varies depending on the patient's age, condition, and severity of symptoms. The usual adult dosage is 75 mg twice daily for the treatment of duodenal and gastric ulcers and 150 mg twice daily for GERD. For Zollinger-Ellison syndrome, the dosage may be as high as 300 mg four times daily.
• The recommended dosage for pediatric patients (12 years and older) with duodenal ulcer is 75 mg twice daily, and for GERD, it is 75-150 mg twice daily.

Common adverse reactions of roxatidine include:

• Headache
• Nausea
• Diarrhea
• Abdominal pain
• Dizziness
• Fatigue

Headache

Abdominal Pain

Dizziness

Fatigue

Before taking roxatidine, patients should be aware of the following warnings and precautions:

• Allergic reactions: Patients who are allergic to roxatidine or any other H2-receptor antagonist should not take this medication.
• Kidney and liver problems: Patients with impaired kidney or liver function should be monitored closely when taking roxatidine, as it may affect their ability to eliminate the drug from their system.
• Cardiovascular effects: H2-receptor antagonists like roxatidine may cause QT interval prolongation and arrhythmias, especially in patients with underlying cardiac disease.
• Gastric malignancy: Roxatidine should not be used to treat gastric ulcers in patients suspected of having gastric malignancy.
• Pregnancy and lactation: The safety of roxatidine during pregnancy and lactation has not been established, and it should only be used if the potential benefits outweigh the potential risks.
• Interactions with other drugs: Roxatidine may interact with other medications, including antacids, anticoagulants, and benzodiazepines.