Medicine details
Image | |
Name | Megacilin |
Dosage | Injection |
Generic Name | Piperacillin + Tazobactam |
Classes |
Antiinfective Agent Antibiotic Antibiotic Combination |
Diseases |
Endometritis Infectious Disease Pneumonia UTI (Urinary Tract Infection) |
Company | Popular Pharmaceuticals Ltd. |
Drug Package Details
Strength | 4 gm + 0.5 gm/vial |
Storage Condition | |
Origin Country | Bangladesh |
Commercial Pack | 1 |
Price per pack | ৳ 1,003.77 |
Cost per pack | ৳ 883.32 |
Package unit | 4.5 gm combipack |
Price per unit | ৳ 1,003.77 |
Cost per unit | ৳ 883.32 |
Discount | 0 |
Coupon | |
Remarks |
Piperacillin + Tazobactam
Piperacillin + Tazobactam is a combination medication used against bacterial infection. Piperacillin kills bacteria by inhibiting cell wall synthesis and tazobactam is a beta lactamase inhibitor. Piperacillin is a broad spectrum antibiotic.
Piperacillin + Tazobactam is indicated for the following infections-
- Intra-abdominal infections
- Skin infections
- Pneumonia (Community acquired/ Nosocomial)
- Female pelvic infections
- The usual daily dose of piperacillin+ tazobactam for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam)
- Dosage in patients with renal impairment (≤40 mL/min of creatinine clearance) and dialysis patients should be reduced, based on the degree of actual renal function impairment.
The common side effects are-
- Rash
- Pruritus
- Nausea
- Vomiting
- Diarrhea
- Serious hypersensitivity reactions (anaphylactic/anaphylactoid) reactions have been reported in patients receiving Piperacillin and tazobactam
- Severe skin disorders like Steven Johnson's syndrome and toxic epidermal necrolysis have also been reported.
- Hematological side effects have been reported, including hemorrhage, leukopenia, and neutropenia. During long-term treatment, keep an eye on your hematologic tests.
- In hemodialysis patients, piperacillin+tazobactam treatment can considerably lower tobramycin concentrations. In these patients, keep an eye on their tobramycin levels.
- Co-administration of piperacillin+tazobactam with vancomycin may increase the incidence of acute kidney injury. Monitor kidney function in patients receiving piperacillin+tazobactam and vancomycin.
- The neuromuscular blockade of vecuronium and other non-depolarizing muscle relaxants may be prolonged by piperacillin+tazobactam.
Contraindication
Piperacillin + Tazobactam is contraindicated in patients who are hypersensitive to any beta lactam antibiotics or beta lactamase inhibitor such as-