Medicine details
| Image |  |
| Name | Angilock PLUS 25/100 |
| Dosage | Tablet |
| Generic Name | Hydrochlorothiazide + Losartan Potassium |
| Classes |
Cardiovascular Agent Antihypertensive Antihypertensive Combination |
| Diseases |
Cardiovascular Disease Hypertension (High Blood Pressure) |
| Company | Square Pharmaceuticals Ltd. |
Drug Package Details
| Strength | 25 mg + 100 mg |
| Storage Condition | |
| Origin Country | Bangladesh |
| Commercial Pack | 30 |
| Price per pack | ৳ 360.98 |
| Cost per pack | ৳ 317.66 |
| Package unit | 10 tabs strip |
| Price per unit | ৳ 12.03 |
| Cost per unit | ৳ 10.59 |
| Discount | 0 |
| Coupon | |
| Remarks |
Hydrochlorothiazide + Losartan Potassium
Hydrochlorothiazide + Losartan Potassium is a combination of losartan potassium an orally active, AT1 receptor subtype specific angiotensin II receptor blocker (ARB), and hydrochlorothiazide, a diuretic.
Hydrochlorothiazide + Losartan Potassium is used to treat the following conditions-
- Hypertension
- Hypertensive patients with left ventricular hypertrophy
Hypertension:
- Losartan potassium and hydrochlorothiazide are used in patients whose blood pressure is not controlled sufficiently by losartan potassium or hydrochlorothiazide alone.
- The usual starting dose of losartan 50 mg/hydrochlorothiazide 12.5 mg once daily. The dosage can be increased after 3 weeks of therapy to a maximum of 100/25 (losartan 100 mg/hydrochlorothiazide 25 mg) once daily as needed to control blood pressure
- For haemodialysis patients, losartan and hydrochlorothiazide pills are not indicated. Patients with significant renal impairment should not take losartan/HCTZ tablets.
- During the second and third trimesters of pregnancy, medications that act on the renin-angiotensin system impair fetal renal function and increase fetal and newborn morbidity and death.
- Symptomatic hypotension can occur in patients with an active renin-angiotensin system, such as volume- and/or salt-depleted patients on high doses of diuretics.
- Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on Hydrochlorothiazide + Losartan Potassium.
Contraindication
- Contraindicated to the patients who are sensitive to hydrochlorothiazide or to other sulfonamide-derived drugs, such as-
- Contraindicated to the patients who are sensitive to Losartan potassium or other ARBs, such as-
- Concomitant use of Hydrochlorothiazide + losartan potassium with aliskiren containing products in patients with diabetes mellitus or renal impairment.
- Hydrochlorothiazide +Losartan potassium is contraindicated in pregnancy.
- Hydrochlorothiazide +Losartan potassium is contraindicated in patients with severe kidney problems (GFR 30 mL/min) and anuria due to the hydrochlorothiazide component.
- Hydrochlorothiazide + Losartan potassium is contraindicated in patients with significant hepatic problems or biliary cirrhosis and cholestasis due to the Telmisartan component.
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